Research Scientist I/II: Pharmacology

Job Description Summary Over 40 therapies in the clinic! NIBR Oncology strives to reimagine medicines for cancer patients through a combination of treatment approaches including targeted therapies, immunotherapies, CAR-T, and radioligand therapy. NIBR is seeking a lab-based in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will join a dynamic, multi-disciplinary team and play a key role in the development and application of in vivo models for evaluating novel cancer therapies and advancing the early-stage drug discovery pipeline. The primary responsibility of this position will be to execute in vivo anti-tumor efficacy and PK/PD studies aimed at evaluating novel drug candidates in CDX, PDX, and syngeneic models. Applicants are expected to spend the majority of their time in the lab. Qualified candidates will be proficient in animal handling techniques and compound administration, while possessing a variety of molecular biology and flow cytometric skills. We are looking for highly motivated, inquisitive, and creative individuals, who thrive in a highly-matrixed work environment, and can effectively communicate within multidisciplinary project teams. Job Description Responsibilities: Hands-on execution of pre-clinical in vivo studies to explore novel hypotheses, screen candidate molecules, and establish proof-of-concept Develop in vivo CDX, PDX, and syngeneic models to evaluate anti-tumor activity, PK/PD relationships, and relevant biomarkers of novel compounds to support clinical development Work independently and in collaboration with other colleagues in pharmacology to execute studies Critically analyze and present results within a multidisciplinary team environment Careful adherence to animal protocols and proper documentation of data and methods in electronic laboratory notebook Qualifications: Research Scientist I position: BS/MS in biological sciences with 2+ years of relevant research experience in pharmaceutical/biotech industry Research Scientist II position: BS/MS in biological sciences with 4+ years of relevant research experience in pharmaceutical/biotech industry Extensive experience working with CDX and PDX xenograft tumor models and/or syngeneic models Experience with cell culture Hands-on mouse/rat handling skills, including dosing (IV, IP, PO), tumor implantation, caliper tumor measurements, xenogen imaging, and blood/tissue collection techniques Experience with PCR, ELISA, western blot, and flow cytometry Strong analytical, communication (written and verbal), and organizational skills, including a proficiency with PowerPoint and commonly used data analysis programs, such as Excel and Prism Novartis Compensation and Benefit Summary: The salary for this position is expected to range between: Research Scientist I: $66,800 - $124,000 per year. Research Scientist II: $81,200 - $150,800 per year The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves. EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $81,200.00 - $150,800.00 Skills Desired Algorithms, Algorithms, Analytical Skill (Inactive), Analytical Thinking, Chemical Biology, Clinical Research, Clinical Trials, Collaboration, Communication Skills (Inactive), Curious Mindset, Data (Inactive), Data Analysis, Design of Experiments (DOE), Detail-Oriented, Diversity and Inclusion (D&I), Drug Discovery Process, Ethics, Hypothesis Testing, Immunology, Laboratory (Inactive), Leading Project Teams, Lifesciences (Inactive), Mammalian Cell Culture, Medical Research, Molecular Biology {+ 6 more}